Abstract Introduction Firstly, the content of this study enriches the indicators related to IIEF-5, which is beneficial for the prevention, diagnosis, and efficacy evaluation of erectile dysfunction (ED). Secondly, the average bedtime discussed in this article is a relatively innovative indicator. Thirdly, this article reflects on the relationship between exercise and immune inflammation. Fourthly, this article divides ED into four levels, providing prevention and treatment strategies for different degrees of ED. This study analyzed the spectrum of pathogenic factors that affect the IIEF-5 score based on the clinical grading of ED. Mild patients need to prioritize adjusting their dietary and nutritional structure and sleep rhythm, while severe patients are recommended to combine regular exercise training with the basic intervention measures mentioned above. This article has certain significance for the prevention and efficacy evaluation of ED, as well as sexual function health care. Objective Few studies have focused on the influencing factors for different degrees of erectile dysfunction (ED). To explore the relationship between IIEF-5 score and possible influencing factors such as blood lipids and immune inflammation in patients with ED. Methods A cross-sectional study was conducted to include ED patients who visited the Men's Clinic of xxxx Hospital, xxxx from June 2023 to December 2024. Multiple factor linear regression analysis was used to explore the influencing factors of IIEF-5 score. Results 183 patients with ED were included, including 41 mild cases, 84 mild to moderate cases, 36 moderate cases, and 22 severe cases. Multivariate regression analysis showed that in mild patients, the influencing factors of IIEF-5 score were average time to sleep per night (β=-0.98, 95% CI=-1.63~-0.12, P=0.009) and LDL-C level (β=-0.78, 95% CI=-1.43~-0.14, P=0.018). In severe ED patients, the influencing factors of IIEF-5 score were monocyte count (β=-9.64, 95% CI=-16.79~-2.50, P=0.011) and systemic immune inflammation index (SII) (β=0.01, 95% CI=0.00~0.02, P=0.019). Conclusions Late bedtime and elevated LDL-C levels may be risk factors for mild ED patients, increased monocyte count may be a risk factor for severe ED patients, and SII may be a protective factor. Clarifying the interfering factors of different grades of ED is beneficial for targeted prevention and treatment. Disclosure No
Zou et al. (Mon,) studied this question.
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