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June 6, 2026

(489) Evaluation of the Relationship Between Sleep Duration, Quality, and Symptom Severity in Patients with Erectile Dysfunction

Key Points

To evaluate the interrelationship between sexual function, sleep quality, and depression in men with erectile dysfunction.
135 men with diagnosed erectile dysfunction were enrolled prospectively from March to June 2025.
Data collected included demographic and biochemical parameters along with questionnaire scores from IIEF-15, SHIM, PEDT, BDI, and MOSS-SS.
Statistical analysis assessed associations between erectile function severity and various parameters.
Higher severity of erectile dysfunction was significantly associated with worse sleep quality (p<0.05).
Free testosterone, FSH, urea, and fasting glucose correlated significantly with erectile dysfunction severity (p<0.05).
Depression severity was prevalent but not significantly correlated with erectile function status.

Abstract

Abstract Introduction Erectile dysfunction (ED) is a multifactorial condition that adversely affects men's physical and psychological healt. Sleep disorders, metabolic imbalance, and depressive symtomps are increasingly recognized as contrubuting factors to the pathophysiology of ED. However, the interrelationship between sexual function, sleep quality and depression remains iinsufficienly defined. Objectives To eveluate sexual function, depression and sleep quality using validated scales, aiming to clarify their interplay and identify potential modifiable risk factors among men with ED. Methods A total of 135 men diagnosed with ED who presented to the Deparment of Urology at Gülhane Training and Research Hospital between March and June 2025 were prospectively enrolled. Data collected included demographic ane biochemical parameters, along with quastionaire score form: IIEF-15, SHIM, PEDT, BDI and MOSS-SS. Associations between erectile function severity and biochemical, sleep and depressive parameters were statistically analyzed. Results Higher ED severity was significantly associated with worse sleep quality, as reflected by higher Sleep Disturbance Index and Sleep Problem Index I and II scores (p0.05). Biochemical variables including free testosterone, FSH, urea and fasting glucose were significantly related to ED severity (p0.05). In contrast, depression severity although prevalent was not significantly correlated with erectile function status. Patients with advanced ED demonstrated both metabolic dysregulation and sleep disruption, suggesting that sleep impairment contributes to the worsening of erectile symptoms. Conclusion Sleep disturbances are strongly and progressively linked to worsening erectile dysfunction, while depressive symptoms are common but not directly determined by erectile function status. Sleep quality should be considered a modifiable risk factor in ED management and integrated evaluation of pyschological and sleep parameters is recommended. Disclosure No No

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