Whipple's disease can involve the porcine leaflets of a Carpentier-Edwards prosthetic cardiac valve, suggesting tissue valves should be avoided in these patients.
Case Report (n=1)
This case report suggests that tissue prosthetic valves should be avoided in patients with Whipple's disease due to the risk of bacterial involvement of the leaflets.
WHIPPLE'S disease is often associated with pancarditis, which may result in major valvular dysfunction.1 2 3 4 5 6 7 We describe a patient in whom Whipple's disease also involved the porcine leaflets of a Carpentier–Edwards prosthetic cardiac valve that had been fixed in glutaraldehyde. This finding supports the view that Whipple's disease is caused by infection with a specific bacterium and suggests that when a patient with Whipple's disease requires a prosthetic cardiac valve, a tissue valve should not be used.Case ReportA 63-year-old man presented in 1967 with a 15-month history of weakness, weight loss, and passage of five to six watery stools . . .
Ratliff et al. (Thu,) conducted a case report in Whipple's disease (n=1). Carpentier-Edwards prosthetic mitral valve (tissue valve) was evaluated on Involvement of porcine leaflets by Whipple's disease. Whipple's disease can involve the porcine leaflets of a Carpentier-Edwards prosthetic cardiac valve, suggesting tissue valves should be avoided in these patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: