Introduction and Objective: Early intensive lifestyle therapy is strongly recommended by diabetes guidelines, yet randomized real-world data in early type 2 diabetes (T2D) remain limited. We evaluated whether a structured, guideline-based lifestyle prescription improves glycemic control and quality of life (QoL) compared with usual care. Methods: In this single-center randomized controlled trial, 380 adults with early T2D were randomized 1:1 to Structured Lifestyle or Usual Care. The intervention included individualized medical nutrition therapy and supervised exercise (≥150 min/week aerobic plus resistance training). The primary outcome was change in HbA1c at 12 months (intention-to-treat). Secondary outcomes included weight, BMI, and WHOQOL-BREF scores. Analyses used mixed-effects models and ANCOVA. Results: Baseline characteristics were well balanced (mean age ~55 years; BMI ~30 kg/m²; HbA1c ~7.8%). At 12 months, the Structured Lifestyle group achieved significantly greater HbA1c and weight reductions and WHOQOL-BREF improvement as shown in image having p0.01is statistically significant. Conclusion: A 12-month structured lifestyle prescription produced clinically meaningful improvements in glycemic control, weight, and patient-reported QoL in early T2D, supporting intensive lifestyle therapy as a high-impact first-line treatment strategy. Disclosure H.N. Prajapati: None. V.D. Bhatt: None. N.R. Shah: None. S. Rohatgi: None. C.N. Hirani: None. D. Bhatt: None.
PRAJAPATI et al. (Fri,) studied this question.