Maternal lipid metabolism in early pregnancy was significantly correlated with markers of insulin resistance and cardiometabolic health, including pre-pregnancy BMI and waist circumference.
Cohort (n=22)
Is lipid metabolism associated with cardiometabolic risk factors in pregnant individuals at risk for preeclampsia?
Lipid metabolism is significantly correlated with insulin resistance and cardiometabolic health indices in early pregnancy among individuals at risk for preeclampsia.
Introduction and Objective: Ineffective lipid metabolism (LM) is a modifiable risk factor associated with cardiometabolic (CM) disease in nongravid populations. Adverse pregnancy outcomes, including pre-eclampsia (PrE), are linked to underlying CM risk. The relationship between LM and CM risk in pregnancy is poorly defined. We aimed to examine associations between maternal LM and CM risk factors among pregnant individuals at risk for PrE. Methods: In this prospective cohort study, whole-body LM was measured using indirect calorimetry before 18 weeks gestation in singleton pregnancies at risk for PrE. Glucose and insulin were serially measured during a 75g-OGTT. Insulin resistance (IR) and CM health were assessed using HOMA-IR, Matsuda and Stumvoll indices. Waist circumference, BMI, and body fat percentage were calculated at the study visits. Insulin AUC was calculated across OGTT time points. IL-6 concentrations were measured via ELISA. Correlations between LM and CM variables were evaluated. Results: Twenty-two participants between 14-18 weeks gestation were included. LM was significantly correlated with markers of IR and CM health, including pre-pregnancy BMI, waist circumference, and body fat percentage (Table). These associations largely persisted after adjustment for pre-pregnancy BMI. Conclusion: LM is associated with IR and CM health in early pregnancy and may influence outcomes. Interventions targeting LM warrant further investigation. Disclosure R. Purvis: None. L. Reyes Fontalvo: None. E. Olatt: None. N. Zite: None. C. Reeder: None. K.B. Fortner: Other - DMC Committee member for RSV vaccine; Current; Pfizer Inc. J.M. Maples: None.
Purvis et al. (Fri,) conducted a cohort in Pregnant individuals at risk for pre-eclampsia (n=22). Maternal lipid metabolism was evaluated on Correlation between lipid metabolism and cardiometabolic risk factors (insulin resistance, BMI, waist circumference, body fat percentage). Maternal lipid metabolism in early pregnancy was significantly correlated with markers of insulin resistance and cardiometabolic health, including pre-pregnancy BMI and waist circumference.