Background CAR T cell therapy is becoming increasingly important in the treatment of haemato-oncological cancers. Knowledge is available on the management of the main side effects and the possible late effects. On the lived experience of patients and their family caregivers and the experiences of nurse there is hardly any knowledge. Current studies show that patients experience that there was no alternative to the treatment decision, that monitoring after the administration of CAR T cells was stressful and that the occurrence of late effects was surprising for them. Research Aim The study examines the experiences of patients and their family caregivers during the trajectory of CAR-T cell therapy; from the decision-making process to the time after CAR-T cell therapy. It follows the main question: How do patients with severe haemato-oncological diseases, their supportive family caregivers and nurses experience and shape CAR T cell therapy? Method A qualitative study design using grounded theory by Charmaz. Data will be obtained using semi-structured interviews with patients and family caregivers and focus group interviews with healthcare professionals. The interviews are going to be recorded, transcribed and analysed. During the process of CAR T cell therapy, the patients and family caregivers interact with each other, with their social environment, with nurses and, when participating in the planned study, with the researcher. To integrate the data from different perspectives, the data will be compared and analyzed for differences and similarities. Results and Conclusion The results are expected to identify the experiences of patients, their family caregivers and nurses. Their needs and wishes for support contribute to the development of a care concept for CAR T cell therapy patients and their family caregivers.
Leinemann et al. (Mon,) studied this question.
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