Maternal SLE and primary Sjögren's syndrome in anti-Ro/SSA-positive pregnancies were associated with a higher rate of growth-retarded babies compared to the general population (10.11% vs 2.2%, P<0.001).
Cohort (n=212)
What is the incidence of congenital heart block and how do maternal autoimmune diseases affect pregnancy outcomes in anti-Ro/SSA-positive women?
Anti-Ro/SSA-positive pregnancies with maternal SLE or Sjögren's syndrome are associated with higher rates of adverse pregnancy outcomes, while the population incidence of autoantibody-related advanced AV block is 1 in 23,300.
Absolute Event Rate: 10.11% vs 2.2%
p-value: p=<0.001
INTRODUCTION: We investigated the effects of maternal autoimmune disease and fetal congenital heart block (CHB) on pregnancy outcomes in anti-Ro/SSA-positive women and assessed the population-based incidence of isolated CHB. MATERIAL AND METHODS: One hundred and ninety nine anti-Ro/SSA-positive pregnancies were prospectively followed at our center (2000-2013). Seven fetuses developed atrioventricular block (AVB) II-III. In this period, another 13 anti-Ro/SSA-positive pregnancies were referred for fetal bradycardia, subsequently diagnosed with AVB II-III. Cesarean section rates, gestational age, body measurements at birth, and the incidence of CHB in these 212 pregnancies were analyzed in relation to fetal atrioventricular conduction and maternal diagnosis and compared with data from the Medical Birth Registry on 352,104 pregnancies in the Stockholm County. RESULTS: The prevalence of maternal systemic lupus erythematosus (SLE) and primary Sjögren's syndrome and the outcomes at birth were similar in normal conduction and AVB I cases. Only 1/20 AVB II-III cases (0/7 in the surveillance group) had a mother diagnosed with SLE, compared with 73/192 in cases with normal conduction or AVB I. Excluding cases with AVB II-III, SLE mothers more frequently delivered by cesarean section (31% vs. 20%, p < 0.05) and had a higher incidence of preterm birth (13% vs. 5.8%, p < 0.05) than the county population. Both SLE and primary Sjögren's syndrome mothers had a fourfold greater rate of growth-retarded babies (10.11% vs. 2.2%, p < 0.001). The incidence of autoantibody-related AVB II-III in Stockholm County was 1/23 300. CONCLUSION: This study of CHB provides new information on the incidence of CHB and outcome of pregnancy in anti-Ro/SSA-positive women, which has clinical relevance when counseling rheumatic patients considering pregnancy.
Skog et al. (Mon,) conducted a cohort in anti-Ro/SSA-positive pregnancies (n=212). Maternal systemic lupus erythematosus (SLE) and primary Sjögren's syndrome vs. County population was evaluated on Rate of growth-retarded babies (p=<0.001). Maternal SLE and primary Sjögren's syndrome in anti-Ro/SSA-positive pregnancies were associated with a higher rate of growth-retarded babies compared to the general population (10.11% vs 2.2%, P<0.001).