Propranolol did not affect the fractional extraction of arterial lactate by the brain during incremental exercise to exhaustion, indicating uptake is passively driven by arterial concentration.
Does propranolol attenuate cerebral lactate uptake during incremental exercise?
Cereal lactate uptake during exercise is passively driven by increasing arterial concentration, challenging previous suggestions of a beta-adrenergic transport mechanism.
During exercise the brain consumes lactate as a substitute for glucose. Propranolol has previously attenuated this cerebral lactate uptake, suggesting a β-adrenergic transport mechanism. However, in the present study, we demonstrate that the fractional extraction of arterial lactate by the brain is unaffected by propranolol throughout incremental exercise to exhaustion. We conclude that cerebral lactate uptake during exercise is passively driven by the increasing arterial concentration, rather than by a β-adrenergic mechanism within the brain.
Siebenmann et al. (Thu,) reported a other. Propranolol was evaluated on fractional extraction of arterial lactate by the brain. Propranolol did not affect the fractional extraction of arterial lactate by the brain during incremental exercise to exhaustion, indicating uptake is passively driven by arterial concentration.
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