What does this research mean for the field?

Mortality related to early-onset Alzheimer's disease in the United States has risen between 2003 and 2023, with notable disparities based on sex, race/ethnicity, and region. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to analyze changes in early-onset Alzheimer’s disease-related mortality across the U.S. over a 20-year period.

June 13, 2026

Rising Mortality Related to Early-Onset Alzheimer’s Disease in the United States: Trends and Disparities 2003–2023 (S15.004)

Key Points

This research aims to analyze changes in early-onset Alzheimer’s disease-related mortality across the U.S. over a 20-year period.
Examined nationwide mortality data from 2003 to 2023.
Analyzed differences based on sex, race/ethnicity, and regional variations.
Rising trends in early-onset Alzheimer's disease-related mortality were identified.
Significant disparities according to sex and race/ethnicity were observed.
Regional variations in mortality rates highlighted systemic inequities.

Abstract

We aimed to examine nationwide demographic trends of early-onset Alzheimer’s disease-related mortality (EOAD-RM) from 2003 to 2023. Additionally, we analyzed differences in EOAD-RM based on sex, race/ethnicity, and region.

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