Obesity is associated with an increased risk of venous thromboembolism, which can be further amplified by interactions with other risk factors such as genetic mutations and oral contraceptive use.
Obesity has emerged as a global health issue that is associated with wide spectrum of disorders, including coronary artery disease, diabetes mellitus, hypertension, stroke, and venous thromboembolism (VTE). VTE is one of the most common vascular disorders in the United States and Europe and is associated with significant mortality. Although the association between obesity and VTE appears to be moderate, obesity can interact with other environmental or genetic factors and pose a significantly greater risk of VTE among individuals who are obese and who are exposed simultaneously to several other risk factors for VTE. Therefore, identification of potential interactions between obesity and certain VTE risk factors might offer some critical points for VTE interventions and thus minimize VTE morbidity and mortality among patients who are obese. However, current obesity measurements have limitations and can introduce contradictory results in the outcome of obesity. To overcome these limitations, this review proposes several future directions and suggests some avenues for prevention of VTE associated with obesity as well.
Yang et al. (Sun,) conducted a review in Venous thromboembolism. Obesity vs. Normal weight was evaluated on Venous thromboembolism. Obesity is associated with an increased risk of venous thromboembolism, which can be further amplified by interactions with other risk factors such as genetic mutations and oral contraceptive use.