ABSTRACT Background Hair mesotherapy is increasingly used in the management of androgenetic alopecia (AGA), yet standardized treatment protocols and controlled clinical data are limited. Aims This study aimed to evaluate the efficacy and safety of a mesotherapy formulation containing biomimetic peptides, vitamins, and micronutrients in patients with AGA. Patients/Methods We conducted a retrospective observational study including 50 patients clinically diagnosed with AGA. Mesotherapy was administered using a mesogun for eight sessions over 3 months. Each session involved 3 mL of mesotherapy solution containing biomimetic peptides, vitamins, and micronutrients. Clinical, trichoscopic, and Trichoscan assessments were performed before treatment and 4 weeks after the final session. Results Post‐treatment, significant improvements were observed in trichoscopic parameters, including reduced hair diameter variability ( p < 0.01), decreased empty follicles ( p = 0.012), and increased upright vellus hairs ( p < 0.01). Trichoscan analysis demonstrated significant increases in total hair count, hair density, average hair thickness, terminal hair density, and terminal hair ratio (all p < 0.001). Treatment was well‐tolerated, with only mild, transient pain reported. Conclusions Hair mesotherapy with biomimetic peptides and micronutrients appears to be a promising and well‐tolerated therapeutic option for AGA. Larger prospective controlled trials are needed to validate these findings.
Köse et al. (Mon,) studied this question.
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