Reply to letter to editor “Clarifying exposure heterogeneity in a review of HERVs and neurodegenerative diseases”

Key Points

• This response aims to clarify the issues surrounding exposure heterogeneity in the context of HERVs and neurodegenerative diseases.
• Analyzed existing literature on HERVs and neurodegenerative diseases.
• Critiqued previously published reviews to highlight gaps in understanding.
• Provided a framework for considering exposure heterogeneity in future research.
• Identified inconsistencies in how exposure to HERVs is measured.
• Emphasized the need for standardized biomarkers in assessing neurodegenerative disease risks.
• Suggested future research directions focused on genetic pathways involved in exposure.