Community Series in: Clinical and Genetic Determinants of Diabetes and Complications -Volume II Diabetes mellitus remains one of the most pressing global health challenges, not only because of its increasing prevalence but also because of its extensive burden of acute and chronic complications (1)(2)(3). Although hyperglycemia is the defining feature of diabetes, its clinical consequences extend far beyond glucose metabolism, involving the retina, kidney, cardiovascular system, liver, nervous system, reproductive health, and immune-metabolic pathways (3,4). The heterogeneity of diabetes across disease type, age, sex, body composition, reproductive history, and comorbid conditions makes uniform approaches to screening and management insufficient (5)(6)(7). Accordingly, contemporary diabetes research is increasingly moving toward earlier risk prediction, biomarker-driven stratification, organ-specific assessment, and individualized intervention. This Research Topic compiles 16 studies that highlight this evolving landscape by integrating evidence from cohort studies, prediction models, systematic reviews, meta-analysis, case reporting, and bibliometric mapping.
Zhang et al. (Fri,) studied this question.