What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypertension (n=23485). Intervention: Hypertension vs. Non-hypertension. Primary outcome: EQ-5D-5L utility index (p=<0.001).

October 18, 2021Open Access

The influencing factors of health-related quality of life among rural hypertensive individuals: a cross-sectional study

Q: What are the key findings of this study?

Hypertension was associated with a significantly lower health-related quality of life compared to non-hypertension among rural adults, with pain/discomfort being the most common problem.

Key Result

Hypertension was associated with a significantly lower health-related quality of life compared to non-hypertension among rural adults, with pain/discomfort being the most common problem.

Study Design

Type

Cross-Sectional (n=23,485)

Structured PICO

Population

23,485 rural adults aged 18-79 years from Henan province, China, including 8,128 with hypertension, assessed for health-related quality of life.

Outcome

Health-related quality of life (HRQoL) assessed via European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L) utility index and Visual Analogue Scale (VAS) scorepatient reported

Hypertension is associated with significantly reduced health-related quality of life in rural populations, a burden that is exacerbated by aging and comorbidities but potentially mitigated by higher socioeconomic status and healthy lifestyles.

Main Result

Absolute Event Rate: 0.94% vs 0.96%

p-value: p=<0.001

Limitations

Cross-sectional study design prevents determining causal relationships between HRQoL and influencing factors.
Four common diseases were integrated into NCDs without detailed description of single diseases, potentially neglecting diverse effects.
Only rural population was included, restricting generalizability to the general population.

Abstract

BACKGROUND: Previous reports regarding health-related quality of life (HRQoL) of hypertensive individuals commonly concentrated on urban population. This study focused on rural population and aimed to explore the influencing factors of HRQoL. METHODS: Date were derived from Henan Rural Cohort study. The HRQoL of participants were assessed via European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L) instrument. Tobit regression model and generalized linear model were employed to explore the influencing factors of HRQoL. Another binary logistic regression was utilized to examine the robustness of our results. RESULTS: Among 23,485 rural population, 8128 participants were identified with hypertension. The mean (SD) utility index and VAS score of non-hypertension group were 0.96 (0.09) and 79.66 (14.20), respectively, while in hypertension group were 0.94 (0.14) and 75.88 (15.50), respectively. Pain/discomfort was the most common self-reported problem (23.05%) for patients. Aging and suffering with other diseases were negatively associated with HRQoL among rural patients, while high socioeconomic status and healthy lifestyles corresponded with high HRQoL. CONCLUSIONS: Hypertension did push considerable pressures on patients' HRQoL. Maintaining healthy lifestyles and improving the socioeconomic status of patients were advisable ways to reduce this burden. Trial registration The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr.org.cn/showproj.aspx?proj=11375.

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