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This study aims to evaluate the long-term risk of heart failure and other adverse cardiac outcomes in sarcoidosis patients compared to matched controls.

June 29, 2026Open Access

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Long-Term Adverse Cardiac Outcomes in Patients With Sarcoidosis

Key Points

This study aims to evaluate the long-term risk of heart failure and other adverse cardiac outcomes in sarcoidosis patients compared to matched controls.
Cohort study of patients aged ≥18 with newly diagnosed sarcoidosis from Danish registries (1996-2016).
Patients were matched 1:4 by age, sex, and comorbidities with a control group without sarcoidosis.
Median follow-up period was 8.2 years.
10-year risk of heart failure was 3.18% for sarcoidosis patients vs. 1.72% for controls (95% CI: 2.83%-3.57% vs. 1.58%-1.86%).
Composite risk of ICD implantation and related issues was 0.96% in patients vs. 0.45% in controls (95% CI: 0.77%-1.18% vs. 0.38%-0.53%).
All-cause mortality was 10.88% for sarcoidosis patients vs. 7.43% for controls (95% CI: 10.23%-11.55% vs. 7.15%-7.72%).

Abstract

BACKGROUND It is estimated that 5% of patients with sarcoidosis have clinically manifest cardiac involvement, although autopsy and imaging studies suggest a significantly higher prevalence of cardiac involvement. There is a paucity of contemporary data on the risk of adverse cardiac outcomes, particularly heart failure (HF), in patients with sarcoidosis. OBJECTIVES The purpose of this study was to examine the long-term risk of HF and other adverse cardiac outcomes in patients with sarcoidosis compared with matched control subjects. METHODS In this cohort study, all patients age ≥18 years with newly diagnosed sarcoidosis (1996 to 2016) were identified through Danish nationwide registries and matched 1:4 by age, sex, and comorbidities with control subjects from the background population without sarcoidosis. RESULTS Of the 12,042 patients diagnosed with sarcoidosis, 11,834 patients were matched with 47,336 subjects from the background population (median age: 42.8 years 25th to 75th percentile: 33.1 to 55.8 years, 54.3% men). The median follow-up was 8.2 years. Absolute 10-year risks of outcomes were as follows: HF: 3.18% (95% confidence interval CI: 2.83% to 3.57%) for sarcoidosis patients and 1.72% (95% CI: 1.58% to 1.86%) for the background population; the composite of ICD implantation, ventricular arrhythmias, and cardiac arrest: 0.96% (95% CI: 0.77% to 1.18%) for sarcoidosis patients and 0.45% (95% CI: 0.38% to 0.53%) for the background population; the composite of pacemaker implantation, atrioventricular block, and sinoatrial dysfunction: 0.94% (95% CI: 0.75% to 1.16%) for sarcoidosis patients and 0.51% (95% CI: 0.44% to 0.59%) for the background population; atrial fibrillation or flutter: 3.44% (95% CI: 3.06% to 3.84%) for sarcoidosis patients and 2.66% (95% CI: 2.49% to 2.84%) for the background population; and all-cause mortality: 10.88% (95% CI: 10.23% to 11.55%) for sarcoidosis patients and 7.43% (95% CI: 7.15% to 7.72%) for the background population. CONCLUSIONS Patients with sarcoidosis had a higher associated risk of HF and other adverse cardiac outcomes compared with matched control subjects.

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Cite This Study

Yafasova et al. (Sat,) studied this question.

synapsesocial.com/papers/6a42e14ee4f09e614277a21d https://doi.org/https://doi.org/10.1016/j.jacc.2020.06.038

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