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This research assesses how chronic arsenic exposure affects thyroid function and blood vessel health.

July 1, 2026

Integrated Endocrine–Endothelial Biomarker Alterations in Chronic Occupational Arsenic Exposure

Key Points

This research assesses how chronic arsenic exposure affects thyroid function and blood vessel health.
Cross-sectional design with 85 arsenic-exposed male workers and 85 controls
Urinary arsenic was measured along with thyroid and endothelial biomarkers
Correlations and multivariable regression analyses were conducted
Exposed workers had lower levels of triiodothyronine and thyroxine but higher thyroid-stimulating hormone (P < 0.001)
Significant increases in ADMA and SDMA concentrations were observed
Urinary arsenic was positively correlated with and predicted ADMA (β = 0.009, P < 0.001) and SDMA (β = 0.003, P < 0.001)

Abstract

OBJECTIVE: To evaluate the effects of chronic occupational arsenic exposure on thyroid homeostasis and endothelial dysfunction using an integrated biomarker approach. METHODS: This cross-sectional study included 85 arsenic-exposed male workers and 85 controls. Urinary arsenic was measured as an exposure biomarker. Thyroid hormones and endothelial biomarkers were analyzed. Correlation and multivariable regression analyses were performed. RESULTS: Exposed workers had lower triiodothyronine and thyroxine levels and higher thyroid-stimulating hormone levels (all P < 0.001). ADMA and SDMA concentrations were significantly elevated. Urinary arsenic correlated with endocrine and endothelial biomarkers and independently predicted ADMA (β = 0.009) and SDMA (β = 0.003) (both P < 0.001). CONCLUSIONS: Chronic occupational arsenic exposure is associated with concurrent endocrine and endothelial alterations, supporting integrated biomarker-based surveillance in occupational health.

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