A 2-hour run decreased arterial stiffness in trained female runners compared to rest, with no change in male runners (interaction P=0.039 for AIx75 and P=0.020 for PWV).
RCT (n=16)
Randomized, crossover
Does a 2-hour run acutely affect arterial stiffness differently in trained male versus female runners?
A 2-hour bout of running acutely decreases arterial stiffness in trained female runners but not in male runners, highlighting a significant gender difference in vascular response to exercise.
p-value: p=0.039 for AIx75, 0.020 for PWV
Arterial stiffness scores over a 5-h period following a 2-h run were measured in trained males (N = 8, age 39.3 ± 2.3 y) and females (N = 8, 35.8 ± 2.8 y). Subjects reported for two lab sessions (randomized, crossover design) from 7:30 am to 4:15 pm, separated by 1-2 weeks, and either rested or ran for 2 h on a treadmill at 75% VO(2 max) from 9:15 to 11:15 am. Augmentation index standardized to a heart rate of 75 bpm (AIx75), and carotid to femoral pulse wave velocity (PWV), were measured by applanation tonometry. Significant interaction effects were measured for AIx75 (P = 0.039) and PWV (P = 0.020), and compared with the rest condition, female runners experienced decreased AIx75 from 11:45 am to 3:15 pm, and in PWV at 11:45 am and 12:15 pm, in contrast to no change in the male runners. These data support a notable gender difference in arterial stiffness following a 2-h bout of running.
Nieman et al. (Tue,) conducted a rct in Healthy trained runners (n=16). 2-hour run on a treadmill vs. Rest condition was evaluated on Arterial stiffness scores (AIx75 and PWV) over a 5-h period (p=0.039 for AIx75, 0.020 for PWV). A 2-hour run decreased arterial stiffness in trained female runners compared to rest, with no change in male runners (interaction P=0.039 for AIx75 and P=0.020 for PWV).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: