July 30, 2008
View Full PaperEnantioselective Nucleophilic Catalysis: The Synthesis of Aza‐β‐Lactams through 2+2 Cycloadditions of Ketenes with Azo Compounds
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Abstract
Get ready for take off: A planar-chiral derivative of 4-pyrrolidinopyridine (1) mediates the title transformation (see scheme) in a convergent manner with good enantioselectivity, thus giving the first catalytic asymmetric synthesis of aza-β-lactams.