Celecoxib use was uniquely associated with aortic stenosis compared to ibuprofen and naproxen in a retrospective electronic medical record analysis.
Observational
Does celecoxib use associate with calcific nodule formation and aortic stenosis?
Celecoxib use is unexpectedly associated with myofibroblast activation, calcific nodule formation, and aortic stenosis, suggesting potential harm regarding calcific aortic valve disease.
Calcific aortic valve disease is a progressive fibrocalcific process that can only be treated with valve replacement. Cadherin-11 has recently been identified as a potential therapeutic target for calcific aortic valve disease. The already approved drug celecoxib, a cyclooxygenase-2 inhibitor, binds cadherin-11, and was investigated as a therapeutic against calcific aortic valve disease. Unexpectedly, celecoxib treatment led to hallmarks of myofibroblast activation and calcific nodule formation in vitro. Retrospective electronic medical record analysis of celecoxib, ibuprofen, and naproxen revealed a unique association of celecoxib use and aortic stenosis.
Bowler et al. (Sat,) conducted a observational in Calcific aortic valve disease / Aortic stenosis. Celecoxib vs. Ibuprofen and naproxen was evaluated on Aortic stenosis. Celecoxib use was uniquely associated with aortic stenosis compared to ibuprofen and naproxen in a retrospective electronic medical record analysis.