The presence of a midwall striae pattern of myocardial fibrosis independently predicted sudden cardiac arrest or appropriate implantable cardiac defibrillator therapy (HR 2.4; 95% CI 1.2-4.6; P=0.01).
Cohort (n=318)
Blinded image interpretation
Does the midwall striae pattern of myocardial fibrosis on LGE-CMR predict sudden cardiac arrest or appropriate ICD therapy in patients with systolic dysfunction?
In patients with systolic dysfunction, a midwall striae pattern of myocardial fibrosis on LGE-CMR is a strong independent predictor of sudden cardiac arrest or appropriate ICD therapy, particularly in those with LVEF >35%.
Hazard Ratio: 2.4 (95% CI 1.2–4.6)
p-value: p=0.01
BACKGROUND: Late gadolinium enhancement-cardiac magnetic resonance is increasingly performed in patients with systolic dysfunction. Numerous patterns of fibrosis are commonly reported among this population. However, the relative prevalence and prognostic significance of these findings remains uncertain. METHODS AND RESULTS: Three hundred eighteen consecutive patients referred for late gadolinium enhancement-cardiac magnetic resonance and a left ventricular ejection fraction 35% (40% versus 6%; P=0.005). CONCLUSIONS: Patients with systolic dysfunction frequently demonstrate multiple patterns of myocardial fibrosis. Of these, a midwall striae pattern of fibrosis is the strongest independent predictor of sudden cardiac arrest or appropriate implantable cardiac defibrillator therapy.
Almehmadi et al. (Fri,) conducted a cohort in Systolic dysfunction (n=318). Midwall striae pattern of myocardial fibrosis vs. Absence of midwall striae pattern was evaluated on Sudden cardiac arrest or appropriate implantable cardiac defibrillator therapy (HR 2.4, 95% CI 1.2-4.6, p=0.01). The presence of a midwall striae pattern of myocardial fibrosis independently predicted sudden cardiac arrest or appropriate implantable cardiac defibrillator therapy (HR 2.4; 95% CI 1.2-4.6; P=0.01).