Chronically administered alpha-hANP significantly reduced systolic blood pressure in both sodium deplete and replete states, while urinary sodium excretion increased only during sodium repletion.
Does chronically administered alpha-hANP reduce blood pressure and increase sodium excretion in SHR and WKY rats under sodium depletion or repletion?
Extracellular fluid volume may be an important determinant of the natriuretic action of ANP, but does not appear to affect its hypotensive effect.
Hypotensive and natriuretic effects of chronically administered alpha-human atrial natriuretic polypeptide (alpha-hANP) were investigated in conscious spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) in both sodium depletion and repletion. Systolic blood pressure was significantly reduced in SHR and WKY in both sodium deplete and replete states. Urinary sodium excretion was significantly increased in SHR and tended to be increased in WKY on sodium repletion, but remained unchanged on sodium depletion. It is suggested that extracellular fluid volume may be an important determinant factor of the natriuretic action of ANP but may not affect the hypotensive effect.
Kondo et al. (Thu,) conducted a other in Hypertension (Spontaneously hypertensive rats). alpha-human atrial natriuretic polypeptide (alpha-hANP) was evaluated on Systolic blood pressure and urinary sodium excretion. Chronically administered alpha-hANP significantly reduced systolic blood pressure in both sodium deplete and replete states, while urinary sodium excretion increased only during sodium repletion.