What question did this study set out to answer?

To investigate how chitosan nanoparticle-delivered siRNA affects the expression of CXCR4 in breast cancer cells and their sensitivity to cisplatin.

July 26, 2026Bioscience Reports0 citationsOpen Access

Expression of Concern: Chitosan nanoparticle-delivered siRNA reduces CXCR4 expression and sensitizes breast cancer cells to cisplatin

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SYShaonan YuUnion Hospital YCYuehua ChenBGI Group (China)XLXuefeng LiUnion Hospital

Key Points

To investigate how chitosan nanoparticle-delivered siRNA affects the expression of CXCR4 in breast cancer cells and their sensitivity to cisplatin.
Analysis of CXCR4 expression levels post siRNA treatment using Western blotting.
Comparison of treated breast cancer cells with control and cisplatin groups.
Concerns raised about the validity of the data presented, particularly regarding Figure 1C and Figure 5B.
No specific numerical outcomes or statistical metrics were provided in the abstract.

Abstract

Bioscience Reports has been made aware of potential issues surrounding the scientific validity of this paper and is hence issuing a permanent Expression of Concern to notify readers.Specifically, it was noted that the second and third Figure 1C CXCR4 bands are highly similar to the first two Figure 5B TLR-4 bands of the article Fang and Jiang, 2016 (DOI: 10.1042/BSR20160118). The authors provided raw data but concerns remain.As such, the article will remain published but with an associated Expression of Concern.

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Expression of Concern: Chitosan nanoparticle-delivered siRNA reduces CXCR4 expression and sensitizes breast cancer cells to cisplatin

Key Points

Abstract

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