Radiofrequency catheter ablation of frequent RVOT-PVC significantly improved left ventricular dimensions, ejection fraction, and NYHA functional class (p<0.05 compared to baseline).
Observational (n=40)
p-value: p=<0.05
OBJECTIVES: The present study evaluated clinical benefits of radiofrequency catheter ablation (RFA) for premature ventricular complexes from right ventricular outflow tract (RVOT-PVC) in patients without structural heart disease. BACKGROUND: It is unknown whether PVC causes left ventricular (LV) dilation, which is a well-recognized precursor of LV dysfunction and heart failure, and whether eliminating PVC by RFA produces clinical benefits in patients with RVOT-PVC. METHODS: Frequency of PVC per total heart beats by 24-h Holter monitoring, left ventricular ejection fraction (LVEF), left ventricular end-diastolic internal dimension (LVDd), mitral regurgitation (MR) by echocardiogram, cardiothoracic ratio (CTR) by chest radiogram, and New York Heart Association (NYHA) functional class of 40 patients with RVOT-PVC without structural heart disease were evaluated before and 6 to 12 months after RFA. RESULTS: Before RFA, a subgroup of patients with frequent (>20%) PVC demonstrated significantly enlarged LVDd and CTR, reduced LVEF, increased MR, and deteriorated NYHA functional class as compared to the subgroup with rare (20%) RVOT-PVC may be a possible cause of LV dysfunction and/or heart failure, and RFA produces clinical benefits in these patients.
Takemoto et al. (Fri,) conducted a observational in Premature ventricular complexes from right ventricular outflow tract (RVOT-PVC) (n=40). Radiofrequency catheter ablation (RFA) vs. Before RFA (baseline) was evaluated on Left ventricular dimensions, ejection fraction, mitral regurgitation, and NYHA functional class (p=<0.05). Radiofrequency catheter ablation of frequent RVOT-PVC significantly improved left ventricular dimensions, ejection fraction, and NYHA functional class (p<0.05 compared to baseline).