Type 1 diabetes mellitus was not associated with increased carotid artery intimal plus medial thickness in children and adolescents compared to healthy controls.
Case-Control (n=95)
Does Type 1 Diabetes Mellitus increase carotid intimal plus medial thickness in children and adolescents?
In children and adolescents, uncomplicated Type 1 Diabetes Mellitus is not associated with increased carotid intimal medial thickness, suggesting early atherosclerosis may not yet be detectable by this method in this age group.
OBJECTIVE: To assess early atherosclerosis using B-mode imaging of the carotid artery in children and adolescents with type 1 diabetes mellitus (T1DM) and to evaluate the relationship between various risk factors and intimal plus medial thickness (IMT) in this population. METHODS: Fifty-two children and adolescents (aged 3-18 years) with uncomplicated T1DM and 43 age- and gender-matched healthy controls were examined. B-mode imaging was used to determine the intimal plus medial thickness (IMT) of the carotid artery in all subjects. Patients with T1DM and control subjects were divided into two groups according to age and gender. Furthermore, duration of DM was considered for comparison. RESULTS: Patients and control subjects showed no association between IMT and sex, systolic blood pressure (sBP), diastolic blood pressure (dBP), serum lipid levels or left ventricular ejection fraction (LVEF). However, statistical analysis indicated a good correlation between age and carotid arterial wall thickness in both diabetic and control groups. These findings were consistent with those in the literature. No correlation was found between IMT and the duration of DM. CONCLUSIONS: This study indicates that there is no association between T1DM and IMT in children and adolescents with T1DM.
Yavuz et al. (Tue,) conducted a case-control in Type 1 Diabetes Mellitus (n=95). Type 1 Diabetes Mellitus vs. Healthy controls was evaluated on Carotid artery intimal plus medial thickness (IMT). Type 1 diabetes mellitus was not associated with increased carotid artery intimal plus medial thickness in children and adolescents compared to healthy controls.