The average lengths of alpha-connectin, beta-connectin, and the 1,200 kDa fragment were estimated to be approximately 1,250, 920, and 360 nm, respectively.
This basic science study provides structural measurements of connectin (titin) and its fragments, estimating alpha-connectin length at approximately 1,250 nm.
Connectin (titin) is an extraordinarily long filamentous protein of striated muscle. The particle lengths of alpha-connectin (titin 1) and its proteolytic products, beta-connectin (titin 2) and 1,200 kDa fragment, were measured with rotary-shadowed images of the filaments after orientation by centrifugation. It was observed that the 1,200 kDa fragment was frequently folded into a double strand, beta-connectin was partly folded, and alpha-connectin was easily split into beta-connectin and 1,200 kDa fragment. Taking these features into consideration, the average lengths of alpha- and beta-connectin and 1,200 kDa fragment were estimated to be approximately 1,250, 920, and 360 nm, respectively.
Suzuki et al. (Mon,) reported a other. Connectin (titin) and its fragments was evaluated on Average lengths of alpha- and beta-connectin and 1,200 kDa fragment. The average lengths of alpha-connectin, beta-connectin, and the 1,200 kDa fragment were estimated to be approximately 1,250, 920, and 360 nm, respectively.
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