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Exercise and Fibrinolysis-Cash and Woodfield BsRfm 661 during the preparation of the 12-month follow-up programme we observed defirite ischaemic changes in the post-exercise electrocardiogram in one of our poor responders-changes which were not present 12 months before.However, one of our original good responders (68%) died after a posterior myocardial infarction in the 12-month interval.Necropsy showed widespread coronary artery atheroma, and on microscopical examination of the thrombus in the right coronary artery it was found that this was probably secondary to haemorrhage into an atheromatous plaque. SummaryThe resting levels of circulating plasminogen activator, as measured by the euglobulin lysis time, and changes following a standard exercise procedure were studied in 25 male and 25 female healthy middle-aged subjects.There was a significantly higher level in the female group.Comparison with previous results obtained from 50 young healthy subjects aged 18-30 years showed no statistically significant difference between the two age groups.There was evidence to indicate that cigarette smoking may have a deleterious effect on the resting level of circulating plasminogen activator.The phenomenon of the poor fibrinolytic responder to exer- cise, previously described in the young subjects, was also shown in the middle-aged population.The middle-aged females had a significantly higher response than the middle-aged males, but there was no significant difference between the total young and middle-aged populations.Cigarette smoking had no in- fluence on the fibrinolytic response to exercise.A 12-month follow-up study on 18 middle-aged subjects confirmed the phenomenon of a poor fibrinolytic response to exercise.
Michael Duff (Sat,) studied this question.