The Obesity Paradox in Heart Failure: Accepting Reality and Making Rational Decisions

The obesity paradox in chronic heart failure (HF) has a number of facets that require discussion. These involve beliefs, various statistical results, and clinical messages. We believe that the paradox is here to stay—the data are just too overwhelming for us to believe otherwise. The main question, however, is what should be the message for patients and their physicians? Clinical Pharmacology & Therapeutics (2011) 90 1, 188–190. doi:10.1038/clpt.2011.72