Current use of SSRIs (HR 1.24; 95% CI 1.07-1.44), tricyclic antidepressants (HR 1.34), and other antidepressants (HR 1.43) was associated with an increased risk of cerebrovascular events.
Case-Control (n=7,601)
Does current antidepressant use increase the risk of cerebrovascular events in patients with depression?
Current use of antidepressants in patients with depression is associated with a significantly increased risk of cerebrovascular events, highlighting the need to consider cardiovascular risk profiles when prescribing these medications.
Hazard Ratio: 1.24 (95% CI 1.07–1.44)
BACKGROUND: Given the widespread use of antidepressants and the negative consequence of cerebrovascular events (CVEs), an evaluation of the risk of CVEs associated with antidepressants is warranted. OBJECTIVE: To examine the association between the use of an antidepressant and risk of CVEs among patients diagnosed with depression. METHODS: A case-control study was performed using a managed care medical claims database from 1998 through 2002. A total of 1086 cases with CVEs were identified and matched with 6515 controls by age, sex, and the year of the index date of depression. Case patients were categorized by stroke type: hemorrhagic stroke, ischemic stroke, and other CVEs. Diagnoses of depression, CVEs, and other medical comorbidities were identified based on International Classification of Diseases, Ninth Revision, codes. Patients were defined as current users (antidepressant ended or =91 days before CVE or nonuse). Cox proportional hazards regression analysis was conducted to estimate the risk of CVEs associated with antidepressant use. RESULTS: A 24% increased risk of a CVE was noted in patients with current exposure to selective serotonin-reuptake inhibitors (SSRIs; adjusted hazard ratio HR 1.24; 95% CI 1.07 to 1.44), 34% increased risk for current exposure to tricyclic antidepressants (HR 1.34; 95% CI 1.10 to 1.62), and 43% increased risk for current exposure to other antidepressants (HR 1.43; 95% CI 1.21 to 1.69). The risk of ischemic stroke in current SSRI users was significantly higher (HR 1.55; 95% CI 1.00 to 2.39) compared with remote/nonusers. CONCLUSIONS: Current users of antidepressants may be at increased risk of a CVE. Clinicians should consider the relationship of antidepressants with the occurrence of CVEs when determining the risk-benefit profile of pharmacologic treatment in patients with depression, particularly those with existing risk factors for a CVE.
Chen et al. (2008) conducted a case-control in Depression (n=7,601). Antidepressant use vs. Remote/nonusers was evaluated on Cerebrovascular events (HR 1.24, 95% CI 1.07 to 1.44). Current use of SSRIs (HR 1.24; 95% CI 1.07-1.44), tricyclic antidepressants (HR 1.34), and other antidepressants (HR 1.43) was associated with an increased risk of cerebrovascular events.