Experimental Infection of Chimpanzees with Human Rhinovirus Types 14 and 43

In three serial experiments, chimpanzees free of specific neutralizing antibody were infected with rhinovirus types 14 or 43. Although infected animals shed virus from 6 to 21 days and produced high levels of specific antibody, clinical illness was not discernible. Providing serum neutralizing antibody was still present, chimpanzees rechallenged with the same agent shed virus for less than 5 hours. To the author's knowledge this is the first report of successful experimental infection by human rhinoviruses of species other than man.