Hypoglycorrhachia with Meningeal Carcinomatosis

Article1 July 1965Hypoglycorrhachia with Meningeal CarcinomatosisReport of Two CasesYOUNG S. KIM, M.D., JEROME S. RESNICK, M.D.YOUNG S. KIM, M.D.Search for more papers by this author, JEROME S. RESNICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-1-115 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years attention has been called to the fact that cerebrospinal fluid glucose may be extremely low and of diagnostic importance in conditions other than the infectious meningitides. Although hypoglycorrhachia was described in 1904 in a case of carcinomatosis of the meninges without infection (1), this phenomenon received little or no attention in the English literature until 1952 when Dodge, Sayre, and Svien (2) reported four cases with metastatic carcinoma in which the metastases involved the meninges and there was associated low cerebrospinal fluid (CSF) glucose. Subsequently, Berg (3) reported five cases of his own, and at that time...References1. RINDFLEISCH W: Ueberdiffuse Sarkomatose der Weichen Hirn—und Ruckenmarkshaute mit Charakteristischem Veranderungen der Cerebrospinalflussigkeit. Deutsch. Z. Nervenheilk. 26: 135, 1904. CrossrefGoogle Scholar2. DODGESAYRESVIEN HWGPHJ: Sugar content of the CSF in diffuse neoplastic involvement of meninges. Proc. Mayo Clin. 27: 259, 1952. MedlineGoogle Scholar3. BERG L: Hypoglycorrhachia of non-infectious origin: diffuse meningeal neoplasia. Neurology 3: 811, 1953. CrossrefMedlineGoogle Scholar4. SPRIGGS A: Malignant cells in CSF. J. Clin. Path. 7: 122, 1954. CrossrefMedlineGoogle Scholar5. MCCORMACKHAZARDGARGNERKLOTZ CJJWJ: Cerebrospinal fluid changes in secondary carcinoma of meninges. Amer. J. Clin. Path. 23: 470, 1953. CrossrefMedlineGoogle Scholar6. FISCHER-WILLIAMSBOSANQUETDANIEL MFDPM: Carcinomatosis of the meninges. Brain 78: 42, 1955. CrossrefMedlineGoogle Scholar7. HAWKINSBROWN DD: Meningeal carcinomatosis. Canad. Med. Ass. J. 88: 225, 1963. MedlineGoogle Scholar8. LEVINSKY WJ: Hypoglycorrhachia in diffuse meningeal neoplasm. New Eng. J. Med. 268: 198, 1963. CrossrefMedlineGoogle Scholar9. PENNEL WH: Boeck's sarcoid with involvement of CNS. Arch. Neurol. Psychiat. (Chicago) 66: 728, 1951. CrossrefGoogle Scholar10. GOLDRINGHARFORD SCG: Effects of leukocytes and bacteria on glucose content of CSF in meningitis. Proc. Soc. Exp. Biol. Med. 75: 669, 1950. CrossrefMedlineGoogle Scholar11. BALTCHOSBORNE AW: Inquiry into causes of lowered spinal fluid sugar content: in vivo and in vitro observations. J. Lab. Clin. Med. 49: 882 1957. MedlineGoogle Scholar12. MCCORDWILLIAMS ARD: Blood CSF barrier in tuberculous meningitis. Arch. Neurol. (Chicago) 7: 247, 1962. Google Scholar13. FISHMAN RA: Carrier transport of glucose between blood and cerebrospinal fluid. Amer. J. Physiol. 206: 836, 1964. CrossrefMedlineGoogle Scholar14. FISHMAN RA: Cerebrospinal fluid, in Clinical Neurology, Vol. 1, edited by BAKER, A. B., Hoeber-Harper, New York, 1962, p. 350. Google Scholar15. FISHMAN RA: Studies of the transport of sugars between blood and cerebrospinal fluid in normal states and in meningeal carcinomatosis. Trans. Amer. Neurol. Ass. 88: 114, 1963. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Department of Medicine, Memorial Hospital for Cancer and Allied Diseases and the James Ewing Hospital, New York, N. Y.Requests for reprints should be addressed to Young S. Kim, M.D., Department of Medicine, Memorial Hospital for Cancer and Allied Diseases, 444 East 68th St., New York, N. Y. 10021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Comparative Treatment of Intraventricular Chemotherapy by Ommaya Reservoir vs. Lumbar Puncture in Patients With Leptomeningeal CarcinomatosisResponse of primary leptomeningeal melanoma to intrathecal recombinant interleukin-2: A case reportRheumatoid Meningitis: A Localized Immune ProcessJOSEPH A. MARKENSON, M.D., J. STEVEN McDOUGAL, M.D., PETER TSAIRIS, M.D., MICHAEL D. LOCKSHIN, M.D., CHARLES L. CHRISTIAN, M.D.General Metabolic Characteristics in CancerCarcinomatous Optic NeuropathyMeningeal carcinomatosis and blindnessVariações da taxa de açúcar no líquido cefalorraqueano em casos de derrame de sangue no espaço sub-aracnóide com especial referência à hipoglicorraquiaMumps Meningoencephalitis with Low Cerebrospinal-Fluid Glucose, Prolonged Pleocytosis and Elevation of ProteinCytology of Cerebrospinal Fluid in the Diagnosis of Malignancy 1 July 1965Volume 63, Issue 1Page: 115-121KeywordsCarcinomatosisCell biologyCerebrospinal fluidDiagnostic medicineGlucoseHospital medicineInfectious diseasesMelanomaMeningesMeningitis Issue Published: 1 July 1965 PDF DownloadLoading ...