Amiodarone-lnduced Ventricular Tachycardia

Brief Reports1 October 1982Amiodarone-lnduced Ventricular TachycardiaDOUGLAS C. WESTVEER, M.D., GERALD A. GADOWSKI, D.O., SEYMOUR GORDON, M.D., GERALD C. TIMMIS, M.D.DOUGLAS C. WESTVEER, M.D.Search for more papers by this author, GERALD A. GADOWSKI, D.O.Search for more papers by this author, SEYMOUR GORDON, M.D.Search for more papers by this author, GERALD C. TIMMIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-4-561 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVirtually all antiarrhythmic agents may facilitate ventricular tachycardia. However, amiodarone has been free of this adverse effect, except in two cases where it was used in combination with disopyramide (1). We report a patient with incessant, polymorphic ventricular tachycardia within 1 week of treatment with amiodarone for paroxysmal ventricular tachycardia.We examined a 64-year-old man who had had four previous episodes of sustained ventricular tachycardia, at heart rates of 180 to 190 beats/min, over an 18-month period. Each episode had produced dyspnea but no syncope, and needed cardioversion. An inferior myocardial infarction had occurred 6 years previously.The electrocardiogram during...References1. KERENTZIVONIGAVISH ADD. Etiology warning signs and therapy of torsade de pointes. Circulation. 1981;64:1167-74. CrossrefMedlineGoogle Scholar2. REYNOLDSVANDER ARK EC. Quinidine syncopy and the delayed repolarization syndromes. Mod Concepts Cardiovasc Dis. 1976;45:117-22. MedlineGoogle Scholar3. NICHOLSONMARTINGRACEYKNOCH WCJH. Disopyramide-induced ventricular fibrillation. Am J Cardiol. 1979;43:1053-5. CrossrefMedlineGoogle Scholar4. SCLARORSKYSTRASBERGLEWINAGMON SBRJ. Polymorphous ventricular tachycardia: clinical features and treatment. Am J Cardiol. 1979;44:339-44. CrossrefMedlineGoogle Scholar5. ROTHMAN M. Prolonged QT interval, atrioventricular block, and torsade de pointes after antiarrhythmic therapy. Br Med J. 1980;280:922-3. CrossrefMedlineGoogle Scholar6. COCCOSTROZZICHUPANSINI GCDR. Torsades de pointes as a manifestation of mexiletine toxicity. Am Heart J. 1980;100:878-80. CrossrefMedlineGoogle Scholar7. ENGLERLEWINTER RM. Tocainide-induced ventricular fibrillation. Am Heart J. 1981;101:494-6. CrossrefMedlineGoogle Scholar8. FONTAINEFRANKWELTIGROSGOGEAT GRJY. Electrophysiology of torsade de pointes. In: MEERE C, ed. Proceedings in the VIth World Symposium on Cardiac Pacing. Montreal: Pacesymp; 1979: Ch 3-6. Google Scholar9. FINERMANPETERMANDEL WTW. Studies on the electrophysiologic effects of amiodarone in man Abstract. Circulation. 1980;62 (suppl III):III-152. Google Scholar10. HAFFAJEEALPERTLESKOCANADA CJLA. Amiodarone for refractory symptomatic tachyarrhythmia Abstract. Circulation. 1980;62 (suppl III):III-152. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: William Beaumont Hospital Royal Oak, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTorsade de Pointes, Ventricular Fibrillation, and Differential Diagnosis of Wide QRS TachycardiasSignificance of aborted cardiac arrest and sustained ventricular tachycardia in patients referred for treatment therapy of advanced heart failureSide effects from amiodaroneAdverse Effects of AmiodaroneElectrophysiologic substrate of torsade de pointes: Dispersion of repolarization or early afterdepolarizations?A general overview of amiodarone toxicity: Its prevention, detection, and managementThe proarrhythmic effects of amiodaroneThe efficacy of amiodarone in the treatment of ventricular tachycardia or ventricular fibrillationEfficacy and toxicity of amiodarone for the treatment of supraventricular tachyarrhythmiasThe long QT syndromes: A critical review, new clinical observations and a unifying hypothesisA Low Incidence of Proarrhythmia Using Low-Dose AmiodaroneWorsening of Ventricular Tachycardia by AmiodaroneAmiodarone in the Management of Cardiac Arrhythmias: Current ConceptsAmiodaroneThe proarrhythmic effects of antiarrhythmic drugsPharmacologic causes of arrhythmogenic actions of antiarrhythmic drugsAmiodaronePhysical Assessment and Differential Diagnosis of the Poisoned PatientTransient exacerbation followed by control of ventricular tachycardia with amiodaroneRelation of serum reverse T3 to amiodarone antiarrhythmic efficacy and toxicityAmiodarone: Pharmacology and Antiarrhythmic and Adverse EffectsLife-threatening Ventricular Arrhythmias Provoked by Amiodarone TreatmentVentricular Tachyarrhythmias in the Long QT SyndromesClinical Use and Pharmacology of AmiodaroneAmiodarone treatment of critical arrhythmias in children and young adultsEffect of amiodarone on serum quinidine and procainamide levelsPolymorphous Ventricular Tachycardia Associated with a Marked Prolongation of the Q-T Interval Induced by AmiodaroneAmiodarone: Electrophysiologic actions, pharmacokinetics and clinical effectsToxic and therapeutic effects of amiodarone in the treatment of cardiac arrhythmiasClinical efficacy of amiodarone in treatment of recurrent ventricular tachycardia and ventricular fibrillationAdverse reactions during treatment with amiodarone hydrochloride.AMIODARONE-A DRUG FOR ALL SEASONS?AMIODARONE THERAPY FOR LIFE THREATENING OR REFRACTORY CARDIAC ARRHYTHMIASAmiodarone and Ventricular TachycardiaJANET M. MCCOMB, M.D., MAZHER M. KHAN, M.B., JOHN S. GEDDES, M.D.Amiodarone and Ventricular TachycardiaNADEMANEE KOONLAWEE, M.D., BRAMAH N. SINGH, M.D. 1 October 1982Volume 97, Issue 4Page: 561-562KeywordsCardiovascular diseasesDyspneaElectrocardiographyHeart rateMyocardial infarctionSyncopeVentricular tachycardia Issue Published: 1 October 1982 PDF DownloadLoading ...