Figure S6 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

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• Main finding indicates that apolipoprotein E from pancreatic neuroendocrine tumors influences tip endothelial cells.
• Key evidence suggests mTOR inhibitors can decrease the proportion of tip endothelial cells and tumor stroma.
• The research employed both cellular models and mTOR inhibitor assays to evaluate tumor-stroma interactions.
• Significance lies in understanding how targeting apolipoprotein E and mTOR pathways can affect cancer progression.