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August 1, 2025

Figure S6 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Xin Lou Yihua Shi Faming Zhao Xiaowu Xu Yan Wang Yi Qin Wuhu Zhang Zeng Ye Fei Wang Tian Ding Desheng Jing Guixiong Fan Yue Zhang Xuemin Chen Jie Chen Xianjun Yu Junfeng Xu Shunrong Ji

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Key Points

Main finding indicates that apolipoprotein E from pancreatic neuroendocrine tumors influences tip endothelial cells.
Key evidence suggests mTOR inhibitors can decrease the proportion of tip endothelial cells and tumor stroma.
The research employed both cellular models and mTOR inhibitor assays to evaluate tumor-stroma interactions.
Significance lies in understanding how targeting apolipoprotein E and mTOR pathways can affect cancer progression.

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Implication

Research shows mTOR inhibitors reduce tumor-stroma and tip endothelial cells in pancreatic cancers, suggesting new treatment avenues.

Abstract

mTOR inhibitors could decrease the tumor stroma and proportion of TipECs

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Cite This Study

Lou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcbf https://doi.org/10.1158/0008-5472.29761013

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S1 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
2Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
3Figure S5 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
4Figure S2 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
5Figure S7 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025