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August 1, 2025

Figure S8 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Xin Lou Yihua Shi Faming Zhao Xiaowu Xu Yan Wang Yi Qin Wuhu Zhang Zeng Ye Fei Wang Tian Ding Desheng Jing Guixiong Fan Yue Zhang Xuemin Chen Jie Chen Xianjun Yu Junfeng Xu Shunrong Ji

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Key Points

Apolipoprotein E from pancreatic neuroendocrine tumors promotes changes in endothelial cells.
This secretion helps remodel the tumor–stroma ratio, impacting cancer progression.
Assessment included primary lesions and live metastasis for ApoE expression.
Understanding these mechanisms may open new strategies for cancer treatment in pancreatic tumors.

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Implication

Research uncovers how apolipoprotein E alters tumor–stroma ratio in pancreatic tumors, suggesting new pathways for cancer progression.

Abstract

ApoE expression in primary lesion and live metastasis

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Cite This Study

Lou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcbc https://doi.org/10.1158/0008-5472.29761004

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S1 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
2Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
3Figure S4 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
4Figure S2 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
5Figure S5 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025