Figure S4 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Xin Lou; Yihua Shi; Faming Zhao; Xiaowu Xu; Yan Wang; Yi Qin; Wuhu Zhang; Zeng Ye; Fei Wang; Tian Ding; Desheng Jing; Guixiong Fan; Yue Zhang; Xuemin Chen; Jie Chen; Xianjun Yu; Junfeng Xu; Shunrong Ji

doi:10.1158/0008-5472.29761022

August 1, 2025

Figure S4 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

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Key Points

Apolipoprotein E influences the remodeling of the tumor-stroma ratio in pancreatic neuroendocrine tumors.
Endothelial cells utilize lipid metabolism for recruiting fibroblasts, supporting tumor progression.
The study highlights a unique interaction between apolipoprotein E and endothelial cells within the tumor microenvironment.
Understanding this mechanism could lead to new strategies for targeting cancer progression in pancreatic neuroendocrine tumors.

Implication

Research demonstrates apolipoprotein E affects endothelial cell lipid metabolism in pancreatic neuroendocrine tumors, suggesting it plays a role in tumor-stroma modulation.

Abstract

ApoE mediated endothelial cell lipid metabolism to affect recruitment of fibroblasts

Discussion

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Cite This Study

Lou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcc0 https://doi.org/10.1158/0008-5472.29761022

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Figure S4 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S4 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Key Points

Implication

Abstract

Discussion

Cite This Study

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