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August 1, 2025

Figure S2 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Xin Lou Yihua Shi Faming Zhao Xiaowu Xu Yan Wang Yi Qin Wuhu Zhang Zeng Ye Fei Wang Tian Ding Desheng Jing Guixiong Fan Yue Zhang Xuemin Chen Jie Chen Xianjun Yu Junfeng Xu Shunrong Ji

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Key Points

MAIN FINDING: Tumor-derived apolipoprotein E promotes tip endothelial cells crucial for tumor progression.
KEY EVIDENCE: Analysis reveals increased remodeling of tumor-stroma ratio linked to apolipoprotein E activity.
APPROACH: The work examines the effects of apolipoprotein E on specific endothelial cell subtypes in pancreatic cancer.
SIGNIFICANCE: This research highlights a key mechanism in cancer progression that could inform therapeutic strategies.

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Implication

Tumor-derived apolipoprotein E enhances tip endothelial cells, indicating it reshapes tumor-stroma ratio and advances cancer growth.

Abstract

Tumor-derived ApoE promoted a subtype of ECs, TipECs

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Cite This Study

Lou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcbe https://doi.org/10.1158/0008-5472.29761031

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S5 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
2Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
3Figure S1 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
4Figure S4 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
5Figure S6 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025