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August 1, 2025

Figure S1 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Xin Lou Yihua Shi Faming Zhao Xiaowu Xu Yan Wang Yi Qin Wuhu Zhang Zeng Ye Fei Wang Tian Ding Desheng Jing Guixiong Fan Yue Zhang Xuemin Chen Jie Chen Xianjun Yu Junfeng Xu Shunrong Ji

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Key Points

MAIN FINDING: Tumor-derived apolipoprotein E significantly influences the tumor-stroma ratio in pancreatic neuroendocrine tumors.
KEY EVIDENCE: A strong correlation exists between apolipoprotein E levels and the presence of a stroma-rich environment in tumors.
APPROACH: The research utilized cellular models to assess the effects of apolipoprotein E on endothelial cells within tumors.
SIGNIFICANCE: Understanding apolipoprotein E's role offers insights into cancer progression and potential therapeutic targets.

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Implication

Research shows tumor-derived apolipoprotein E affects endothelial cells in pancreatic tumors, suggesting it influences cancer growth.

Abstract

Tumor-derived ApoE correlated with the stroma-rich environment

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Cite This Study

Lou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcae https://doi.org/10.1158/0008-5472.29761034

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
2Figure S4 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
3Figure S8 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
4Figure S2 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
5Figure S6 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025