Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Xin Lou; Yihua Shi; Faming Zhao; Xiaowu Xu; Yan Wang; Yi Qin; Wuhu Zhang; Zeng Ye; Fei Wang; Tian Ding; Desheng Jing; Guixiong Fan; Yue Zhang; Xuemin Chen; Jie Chen; Xianjun Yu; Junfeng Xu; Shunrong Ji

doi:10.1158/0008-5472.29761025

August 1, 2025

Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

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Key Points

Apolipoprotein E increases the tumor-stroma ratio in pancreatic neuroendocrine tumors.
This secretion leads to a richer stroma, which is associated with enhanced tumor progression.
Endothelial cells are induced by apoE to remodel the tumor environment.
Understanding these mechanisms can inform strategies targeting the tumor microenvironment in cancer therapy.

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Implication

Pancreatic neuroendocrine tumors secrete apoE to enhance local stroma and cancer progression, indicating its significant role in tumor microenvironment dynamics.

Abstract

ApoE promoted a stroma-rich microenvironment and tumor progression.

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Cite This Study

Lou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcbb https://doi.org/10.1158/0008-5472.29761025

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Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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