Figure S5 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Xin Lou; Yihua Shi; Faming Zhao; Xiaowu Xu; Yan Wang; Yi Qin; Wuhu Zhang; Zeng Ye; Fei Wang; Tian Ding; Desheng Jing; Guixiong Fan; Yue Zhang; Xuemin Chen; Jie Chen; Xianjun Yu; Junfeng Xu; Shunrong Ji

doi:10.1158/0008-5472.29761016

August 1, 2025

Figure S5 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

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Key Points

Core finding: Apolipoprotein E drives changes in the tumor–stroma ratio, promoting cancer progression in pancreatic neuroendocrine tumors.
Evidence shows that tip endothelial cells influence tumor recruitment of fibroblasts, playing a pivotal role in cancer dynamics.
The research utilized cellular assays to investigate the interaction between apolipoprotein E and endothelial cells in tumor environments.
These findings could lead to novel therapeutic strategies targeting the tumor–stroma interactions in pancreatic neuroendocrine tumors.

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Implication

Research reveals that apolipoprotein E alters the tumor–stroma ratio in pancreatic neuroendocrine tumors, indicating the role of tip endothelial cells in cancer advancement.

Abstract

The mechanisms by which the TipECs recruited fibroblasts

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Lou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcc4 https://doi.org/10.1158/0008-5472.29761016

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Figure S5 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Figure S5 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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