⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

August 1, 2025

Figure S7 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Xin Lou Yihua Shi Faming Zhao Xiaowu Xu Yan Wang Yi Qin Wuhu Zhang Zeng Ye Fei Wang Tian Ding Desheng Jing Guixiong Fan Yue Zhang Xuemin Chen Jie Chen Xianjun Yu Junfeng Xu Shunrong Ji

View Full Paper

Ask AI

Bookmark

Share

Key Points

Apolipoprotein E from pancreatic neuroendocrine tumors influences endothelial cells to alter tumor–stroma ratio.
mTOR inhibitors combined with PEGPH20 significantly improve treatment effects in tumor progression.
The interaction between cancer cells and the stroma plays a vital role in shaping tumor development.
Findings may lead to new therapeutic strategies targeting the tumor microenvironment in cancer.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Research shows mTOR inhibitors enhance PEGPH20 effectiveness in pancreatic neuroendocrine tumors, suggesting improved cancer treatment options.

Abstract

mTOR inhibitors enhanced the effectiveness of PEGPH20

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Lou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcc1 https://doi.org/10.1158/0008-5472.29761007

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S6 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
2Figure S4 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
3Figure S3 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
4Figure S1 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025
5Figure S8 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression2025