Figure S8 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Puntos clave

• B7-H3 CAR T cells demonstrate effectiveness against ependymomas, but limitations arise from tumor size.
• There is an inverse correlation noted between B7-H3 density on ependymoma cells and the upregulation of B7-H3 antigen on CAR T cells.
• Observational study on ependymomas highlights the impact of immune response on CAR T cell function.
• Results indicate potential for targeting B7-H3 but also point to challenges posed by tumor immune context.