Figure S8 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta; Siri Ippagunta; Srinidhi Varadharajan; Alisha Kardian; Nic Laboe; Diana Dinh; Amber B. Jones; Michaela Meehl; Jorge Ibañez-Vega; Erik Emanus; Tram Dao; Meghan B. Ward; Wilda Orisme; Shannon Lange; Deanna Langfitt; Jeffrey Steinberg; Jason Chiang; Peter Vogel; Heather Sheppard; David W. Ellison; Stephen C. Mack; Giedre Krenciute

doi:10.1158/1078-0432.30028490

Key Points

B7-H3 CAR T cells demonstrate effectiveness against ependymomas, but limitations arise from tumor size.
There is an inverse correlation noted between B7-H3 density on ependymoma cells and the upregulation of B7-H3 antigen on CAR T cells.
Observational study on ependymomas highlights the impact of immune response on CAR T cell function.
Results indicate potential for targeting B7-H3 but also point to challenges posed by tumor immune context.

Implication

Observational analysis shows lower B7-H3 density limits CAR T-cell effectiveness against ependymomas, suggesting immune response plays a crucial role.

Abstract

Figure S8 shows inverse correlation between B7-H3 antigen upregulation on B7-H3.CAR T-cells post co-culture and B7-H3 density on EPN cells.

Discussion

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029f1 https://doi.org/10.1158/1078-0432.30028490

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Figure S8 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S8 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

Implication

Abstract

Discussion

Cite This Study

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