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September 2, 2025Open Access

Figure S12 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

HER2.CAR T-cells showed improved cell persistence compared to B7-H3.CAR T-cells against EPN cells, enhancing therapeutic potential.
The effectiveness of CAR T-cells against ependymomas is limited by tumor size and the overall immune response within the tumor environment.
Studies indicate that tumor size affects CAR T-cell activity, potentially reducing their efficacy in larger tumors, a concern for treating ependymomas.
Improving CAR T-cell expansion and persistence is crucial for combating ependymomas, particularly in the context of immune suppression.

Implication

Figures reveal that HER2.CAR T-cells improve persistence over B7-H3.CAR T-cells in ependymomas, highlighting challenges related to tumor size.

Abstract

Figure S12 shows improved expansion and persistence of HER2.CAR T-cells over B7-H3.CAR T-cells against EPN cells.

Discussion

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02993 https://doi.org/10.1158/1078-0432.30028547

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S13 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
2Figure S6 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
3Figure S19 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
4Figure S15 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
5Figure S11 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025

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