Figure S11 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

B7-H3 CAR T cells are effective against ependymomas, but their efficacy is limited by tumor size and the immune response.
The analysis of human HER2.CAR T-cells reveals critical phenotypic characteristics relevant to their targeting capabilities.
Observational analysis on the role of tumor size and immune response is essential for understanding CAR T cell efficacy.
Understanding the limitations of immune response can guide potential improvements in CAR T cell therapies against ependymomas.

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Observational analysis finds that B7-H3 CAR T cells effectively target ependymomas, highlighting limits imposed by tumor size and immune response.

Figure S11 shows phenotypic characteristics of human HER2.CAR T-cells.

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Mehta et al. (2025) studied this question.

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