Figure S15 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta; Siri Ippagunta; Srinidhi Varadharajan; Alisha Kardian; Nic Laboe; Diana Dinh; Amber B. Jones; Michaela Meehl; Jorge Ibañez-Vega; Erik Emanus; Tram Dao; Meghan B. Ward; Wilda Orisme; Shannon Lange; Deanna Langfitt; Jeffrey Steinberg; Jason Chiang; Peter Vogel; Heather Sheppard; David W. Ellison; Stephen C. Mack; Giedre Krenciute

doi:10.1158/1078-0432.30028535

Key Points

Increased inhibitory marker expression in B7-H3 CAR T-cells highlights a significant immune response.
The study shows limitations for these CAR T-cells against ependymomas due to tumor size and immune interactions.
Findings were derived through analysis comparing B7-H3 and HER2 CAR T-cells under repeated stimulation.
Research suggests potential therapeutic challenges for CAR T-cells in large tumors with strong immune responses.

Implication

Observational analysis finds that B7-H3 CAR T-cells exhibit increased inhibitory marker expression, indicating limitations due to tumor size and immune response.

Abstract

Figure S15 shows increased inhibitory marker expression on B7-H3.CAR T-cells compared to HER2.CAR T-cells following repeated stimulation with 1425 cell line.

Discussion

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029ed https://doi.org/10.1158/1078-0432.30028535

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Figure S15 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S15 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

Implication

Abstract

Discussion

Cite This Study

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