Figure S14 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

B7-H3 car T cells show effectiveness against ependymomas, but their efficacy is limited by tumor size.
A pivotal comparison reveals that the immune response affects the effectiveness of B7-H3 car T cells.
The study utilized a cell line to analyze the phenotypic characteristics during repeated stimulation.
Findings suggest improvements in targeting and understanding immune barriers may enhance treatment outcomes.

Analysis identifies how b7-h3 car t cells compare against her2 car t cells, highlighting limitations from tumor size and immune response.

Figure S14 shows comparison of phenotypic characteristics between B7-H3.CAR and HER2.CAR T-cells during repeated stimulation with 1425 cell line.

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Mehta et al. (2025) studied this question.

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