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September 2, 2025Open Access

Figure S18 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

Antitumor efficacy of B7-H3 CAR T cells decreases as tumor size increases, and immune response plays a crucial role.
The study demonstrates the relationship between tumor volume and CAR T cell efficacy, emphasizing immune response limits.
The findings reveal that CAR T cells are a promising approach for treating Ependymomas but face critical limitations.
Understanding these limitations is vital for improving CAR T cell therapy outcomes in patients with Ependymomas.

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Implication

Figure S18 highlights antitumor efficacy of CAR T cells in Ependymomas, indicating size and immune factors limit effectiveness.

Abstract

Figure S18 shows tumor volume-dependent antitumor efficacy of HER2.CAR T-cells.

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029af https://doi.org/10.1158/1078-0432.30028526

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S11 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
2Figure S15 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
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4Figure S14 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
5Figure S19 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025

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