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September 2, 2025Open Access

Figure S19 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

Successful infiltration of HER2.CAR T-cells was observed in ependymoma tumors, but efficacy is constrained.
Infiltration was successful in 1425 EPN xenograft tumors, highlighting potential for CAR T-cell therapy.
Tumor size and immune response emerged as critical factors impacting the effectiveness of CAR T cells.
Challenges arise due to the size of tumors and the inflammatory response, suggesting areas for future research.

Implication

Observational analysis revealed that CAR T cells infiltrate ependymomas effectively, indicating immune response limits efficacy.

Abstract

Figure S19 shows successful infiltration of HER2.CAR T-cells inside 1425 EPN xenograft tumors.

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029bf https://doi.org/10.1158/1078-0432.30028523

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S12 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
2Figure S13 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
3Figure S18 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
4Figure S17 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
5Figure S6 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025

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