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September 2, 2025Open Access

Figure S16 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

B7-H3 CAR T-cells demonstrated high efficacy against xenograft tumors, but their effectiveness is limited by tumor size.
Durability of B7-H3 CAR T-cells is less robust in the presence of an immune response, affecting treatment outcomes.
Xenograft models in vivo highlighted the complexity of using B7-H3 CAR T-cell therapy against ependymomas.
Size and immune interference present significant challenges in optimizing B7-H3 CAR T-cell treatments for ependymomas.

Implication

In vivo observations reveal B7-H3 CAR T-cells' potency against ependymomas, indicating challenges with tumor size and immune response.

Abstract

Figure S16 shows high potency but limited durability of B7-H3.CAR T-cells against ZFTA-RELA EPN xenograft tumors in vivo.

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029cc https://doi.org/10.1158/1078-0432.30028532

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1Figure S20 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
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