Figure S21 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• B7-H3 CAR T cells show effectiveness against ependymomas, but their impact is limited by tumor size and immune response.
• IHC evaluation reveals significant immune cell infiltration within the ZFTA-RELA EPN tumors, indicating ongoing immune activity.
• Analysis was conducted on syngeneic ZFTA-RELA EPN tumors to assess immune cell dynamics following treatment.
• Findings highlight the need to consider tumor size and immune interactions in developing CAR T cell therapies.