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September 2, 2025Open Access

Figure S21 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Sanya Mehta Siri Ippagunta Srinidhi Varadharajan Alisha Kardian Nic Laboe Diana Dinh Amber B. Jones Michaela Meehl Jorge Ibañez-Vega Erik Emanus Tram Dao Meghan B. Ward Wilda Orisme Shannon Lange Deanna Langfitt Jeffrey Steinberg Jason Chiang Peter Vogel Heather Sheppard David W. Ellison Stephen C. Mack Giedre Krenciute

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Key Points

B7-H3 CAR T cells show effectiveness against ependymomas, but their impact is limited by tumor size and immune response.
IHC evaluation reveals significant immune cell infiltration within the ZFTA-RELA EPN tumors, indicating ongoing immune activity.
Analysis was conducted on syngeneic ZFTA-RELA EPN tumors to assess immune cell dynamics following treatment.
Findings highlight the need to consider tumor size and immune interactions in developing CAR T cell therapies.

Implication

IHC analysis reveals immune cell infiltration in ependymomas, suggesting immune response may limit effectiveness.

Abstract

Figure S21 shows IHC evaluation and quantification of immune cell infiltration inside syngeneic ZFTA-RELA EPN tumors.

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Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd029a5 https://doi.org/10.1158/1078-0432.30028514

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S22 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
2Figure S20 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response2025
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